Synthesis and anti-tubulin activity of ustiloxin D derivatives.
نویسندگان
چکیده
Ustiloxin D, produced by the rice plant pathogen Ustilaginoidea virens, exhibits potent anti-tubulin activity. In order to elucidate the effects of functional groups in ustiloxin D on its activity, several derivatives were synthesized and their anti-tubulin activities were estimated. The N,N-dimethylamino derivative and the 14-O-methyl derivative were inactive (IC50 > 50 microM). 20-Hydroxymethylated ustiloxin D showed decreased inhibitory activity compared with ustiloxin D.
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ورودعنوان ژورنال:
- The Journal of antibiotics
دوره 51 4 شماره
صفحات -
تاریخ انتشار 1998